Structural Brain Changes in Pre-Clinical FTD MAPT Mutation Carriers.
J Alzheimers Dis
; 75(2): 595-606, 2020.
Article
en En
| MEDLINE
| ID: mdl-32310161
ABSTRACT
BACKGROUND:
Frontotemporal dementia (FTD) is the second most common cause of early-onset neurodegenerative dementia. Several studies have focused on early imaging changes in FTD patients, but once subjects meet full criteria for FTD diagnosis, structural changes are generally widespread.OBJECTIVE:
This study aims to determine the earliest structural brain changes in asymptomatic MAPT MUTATION carriers.METHODS:
This is a cross-sectional multicenter study comparing global and regional brain volume and white matter integrity in a group of MAPT mutation preclinical carriers and controls. Participants belong to multiple generations of six families with five MAPT mutations. All participants underwent a medical examination, neuropsychological tests, genetic analysis, and a magnetic resonance scan (3T, scout, T1-weighted image followed by EPI (BOLD), MPRAGE, DTI, FLAIR, and ASL sequences).RESULTS:
Volumes of five cortical and subcortical areas were strongly correlated with mutation status temporal lobe (left amygdala, left temporal pole), cingulate cortex (left rostral anterior cingulate gyrus, right posterior cingulate), and the lingual gyrus in the occipital lobe. We did not find significant differences in whole brain volume, white matter hyperintensities volume, and white matter integrity using DTI analysis.CONCLUSION:
Temporal lobe, cingulate cortex and the lingual gyrus seem to be early targets of the disease and may serve as biomarkers for FTD prior to overt symptom onset.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Encéfalo
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Proteínas tau
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Demencia Frontotemporal
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Sustancia Blanca
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Heterocigoto
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Mutación
Tipo de estudio:
Clinical_trials
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Observational_studies
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Prevalence_studies
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Risk_factors_studies
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Screening_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2020
Tipo del documento:
Article