Gram-scale preparation of the antibiotic lead compound salicyl-AMS, a potent inhibitor of bacterial salicylate adenylation enzymes.
Methods Enzymol
; 638: 69-87, 2020.
Article
en En
| MEDLINE
| ID: mdl-32416922
ABSTRACT
Salicyl-AMS (1) is a potent inhibitor of salicylate adenylation enzymes used in bacterial siderophore biosynthesis and a promising lead compound for the treatment of tuberculosis. An optimized, multigram synthesis is presented, which provides salicyl-AMS as its sodium salt (1·Na) in three synthetic steps followed by a two-step salt formation process. The synthesis proceeds in 11.6% overall yield from commercially available adenosine 2',3'-acetonide and provides highly purified material.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Antibacterianos
/
Mycobacterium tuberculosis
Idioma:
En
Año:
2020
Tipo del documento:
Article