Glucose fluctuations promote vascular BK channels dysfunction via PKC&#945;/NF-&#954;B/MuRF1 signaling.

Zhang, Zhen-Ye; Qian, Ling-Ling; Wang, Ning; Miao, Ling-Feng; Ma, Xin; Dang, Shi-Peng; Wu, Ying; Liu, Xiao-Yu; Li, Xiao-Yan; Chai, Qiang; Pan, Min; Yi, Fu; Ling, Tian-You; Wang, Ru-Xing

Glucose fluctuations promote vascular BK channels dysfunction via PKCα/NF-κB/MuRF1 signaling.

Zhang, Zhen-Ye; Qian, Ling-Ling; Wang, Ning; Miao, Ling-Feng; Ma, Xin; Dang, Shi-Peng; Wu, Ying; Liu, Xiao-Yu; Li, Xiao-Yan; Chai, Qiang; Pan, Min; Yi, Fu; Ling, Tian-You; Wang, Ru-Xing.

Afiliación

Zhang ZY; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Qian LL; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Wang N; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Miao LF; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Ma X; School of Pharmaceutical Sciences, Jiangnan University, Wuxi, China.
Dang SP; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Wu Y; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Liu XY; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Li XY; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China.
Chai Q; Department of Physiology, Institute of Basic Medicine, Shandong Academy of Medical Sciences, Jinan, China.
Pan M; Department of Cardiology, Affiliated Hospital Nantong University, Nantong, China.
Yi F; Department of Cardiovascular Diseases, Xijing Hospital, Fourth Military Medical University, Xi'an, China.
Ling TY; Department of Cardiology, Ruijin Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Wang RX; Department of Cardiology, The Affiliated Wuxi People's Hospital of Nanjing Medical University, Wuxi 214023, China. Electronic address: ruxingw@aliyun.com.

J Mol Cell Cardiol ; 145: 14-24, 2020 08.

Article en En | MEDLINE | ID: mdl-32511969

Asunto(s)

Vasos Coronarios/metabolismo; Vasos Coronarios/fisiopatología; Glucosa/toxicidad; Canales de Potasio de Gran Conductancia Activados por el Calcio/metabolismo; FN-kappa B/metabolismo; Proteína Quinasa C-alfa/metabolismo; Transducción de Señal; Ubiquitina-Proteína Ligasas/metabolismo; Animales; Células Cultivadas; Regulación hacia Abajo/efectos de los fármacos; Humanos; Insulina/metabolismo; Malondialdehído/sangre; Miocitos del Músculo Liso/efectos de los fármacos; Miocitos del Músculo Liso/metabolismo; Subunidades de Proteína/metabolismo; Proteolisis/efectos de los fármacos; Ratas Sprague-Dawley; Especies Reactivas de Oxígeno/metabolismo; Transducción de Señal/efectos de los fármacos

Palabras clave

Glucose fluctuation; Large conductance calcium activated potassium channel; Muscle ring finger protein 1; Nuclear factor-κB; Protein kinase Cα; Reactive oxygen species

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Transducción de Señal / FN-kappa B / Vasos Coronarios / Ubiquitina-Proteína Ligasas / Proteína Quinasa C-alfa / Canales de Potasio de Gran Conductancia Activados por el Calcio / Glucosa Tipo de estudio: Prognostic_studies Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

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