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A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat.
Abrams, Ruth; Kaddi, Chanchala D; Tao, Mengdi; Leiser, Randolph J; Simoni, Giulia; Reali, Federico; Tolsma, John; Jasper, Paul; van Rijn, Zachary; Li, Jing; Niesner, Bradley; Barrett, Jeffrey S; Marchetti, Luca; Peterschmitt, M Judith; Azer, Karim; Neves-Zaph, Susana.
Afiliación
  • Abrams R; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Kaddi CD; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Tao M; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Leiser RJ; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Simoni G; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
  • Reali F; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
  • Tolsma J; RES Group Inc, Needham, Massachusetts, USA.
  • Jasper P; RES Group Inc, Needham, Massachusetts, USA.
  • van Rijn Z; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Li J; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Niesner B; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Barrett JS; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Marchetti L; Fondazione The Microsoft Research - University of Trento Centre for Computational and Systems Biology (COSBI), Rovereto, Italy.
  • Peterschmitt MJ; Sanofi Genzyme, Cambridge, Massachusetts, USA.
  • Azer K; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
  • Neves-Zaph S; Translational Disease Modelling, Digital Data Science, Sanofi, Bridgewater, New Jersey, USA.
CPT Pharmacometrics Syst Pharmacol ; 9(7): 374-383, 2020 07.
Article en En | MEDLINE | ID: mdl-32558397
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Biología de Sistemas / Enfermedad de Gaucher / Modelos Biológicos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirrolidinas / Biología de Sistemas / Enfermedad de Gaucher / Modelos Biológicos Tipo de estudio: Etiology_studies / Prognostic_studies Límite: Adult / Humans Idioma: En Año: 2020 Tipo del documento: Article