Regulating the pH of bicarbonate solutions without purging gases: Application to dissolution testing of enteric coated tablets, pellets and microparticles.

Scott, Nathan; Patel, Kavil; Sithole, Tariro; Xenofontos, Konstantina; Mohylyuk, Valentyn; Liu, Fang

Scott, Nathan; Patel, Kavil; Sithole, Tariro; Xenofontos, Konstantina; Mohylyuk, Valentyn; Liu, Fang.

Afiliación

Scott N; Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom.
Patel K; Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom.
Sithole T; Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom.
Xenofontos K; Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom.
Mohylyuk V; Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom.
Liu F; Department of Clinical and Pharmaceutical Sciences, University of Hertfordshire, Hatfield AL10 9AB, United Kingdom; Fluid Pharma Ltd, Nexus, Discovery Way, Leeds LS2 3AA, United Kingdom. Electronic address: f.liu3@herts.ac.uk.

Int J Pharm ; 585: 119562, 2020 Jul 30.

Article en En | MEDLINE | ID: mdl-32565282

Asunto(s)

Bicarbonatos/química; Química Farmacéutica/métodos; Gases/química; Solubilidad; Comprimidos Recubiertos/química; Tampones (Química); Liberación de Fármacos; Hidrodinámica; Concentración de Iones de Hidrógeno; Modelos Biológicos

Palabras clave

Bicarbonate; Biorelevant; Dissolution; Enteric coating; In vitro testing

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Solubilidad / Comprimidos Recubiertos / Bicarbonatos / Química Farmacéutica / Gases Idioma: En Año: 2020 Tipo del documento: Article

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