Design, synthesis and neuropharmacological evaluation of new 2,4-disubstituted-1,5-benzodiazepines as CNS active agents.

Verma, Ramesh; Bhatia, Rohit; Singh, Gurpreet; Kumar, Bhupinder; Mehan, Sidharth; Monga, Vikramdeep

Verma, Ramesh; Bhatia, Rohit; Singh, Gurpreet; Kumar, Bhupinder; Mehan, Sidharth; Monga, Vikramdeep.

Afiliación

Verma R; Department of Pharmaceutical Chemistry, Rajendra Institute of Technology & Sciences, Sirsa 125055, Haryana, India.
Bhatia R; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga 142001, Punjab, India.
Singh G; Department of Pharmaceutical Chemistry, Rajendra Institute of Technology & Sciences, Sirsa 125055, Haryana, India; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga 142001, Punjab, India.
Kumar B; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga 142001, Punjab, India.
Mehan S; Department of Pharmacology, Rajendra Institute of Technology & Sciences, Sirsa 125055, Haryana, India; Department of Pharmacology, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga 142001, Punjab, India.
Monga V; Department of Pharmaceutical Chemistry, Rajendra Institute of Technology & Sciences, Sirsa 125055, Haryana, India; Department of Pharmaceutical Chemistry, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga 142001, Punjab, India. Electronic address: vikramdeepmonga@gmail.com.

Bioorg Chem ; 101: 104010, 2020 08.

Article en En | MEDLINE | ID: mdl-32615464

Asunto(s)

Anticonvulsivantes/farmacología; Antidepresivos/farmacología; Benzodiazepinas/química; Benzodiazepinas/farmacología; Fármacos del Sistema Nervioso Central/química; Fármacos del Sistema Nervioso Central/farmacología; Diseño de Fármacos; Animales; Anticonvulsivantes/química; Antidepresivos/química; Conducta Animal/efectos de los fármacos; Benzodiazepinas/síntesis química; Fármacos del Sistema Nervioso Central/síntesis química; Simulación por Computador; Simulación del Acoplamiento Molecular; Ratas; Receptores de GABA-A/efectos de los fármacos; Relación Estructura-Actividad

Palabras clave

1,5-Benzodiazepine; Anticonvulsant; CNS depressant; Docking; GABAA receptor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Benzodiazepinas / Diseño de Fármacos / Fármacos del Sistema Nervioso Central / Anticonvulsivantes / Antidepresivos Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2020 Tipo del documento: Article

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