Serum aminoterminal type III procollagen peptide in inflammatory and degenerative rheumatic disorders.
Clin Rheumatol
; 7(1): 61-8, 1988 Mar.
Article
en En
| MEDLINE
| ID: mdl-3261674
ABSTRACT
Measurement of the aminoterminal type III procollagen peptide in serum has been suggested as a marker of the biosynthesis of collagen type III, a major connective tissue component in repair processes. In the present study the propeptide level correlated with the inflammatory synovial mass in rheumatoid arthritis and osteoarthritis. This implies that the propeptide level reflects the collagen type III synthesis occurring in the synovial repair processes, whether they were caused by inflammatory or degenerative rheumatic disorders. Physical activity did not enhance the transition of the propeptide from the synovial fluid or the inflamed synovial membrane to the blood. Normal serum propeptide values were observed in most patients with ankylosing spondylitis and degenerative diseases of the spine. This may reflect the lower amount of inflammatory tissue in these diseases and hence the sensitivity of the assays.
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Banco de datos:
MEDLINE
Asunto principal:
Fragmentos de Péptidos
/
Enfermedades Reumáticas
/
Procolágeno
Tipo de estudio:
Observational_studies
/
Prevalence_studies
/
Risk_factors_studies
Límite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Año:
1988
Tipo del documento:
Article