Reactive Dicarbonyl Scavenging Effectively Reduces MPO-Mediated Oxidation of HDL and Restores PON1 Activity.

Huang, Jiansheng; Yancey, Patricia G; Tao, Huan; Borja, Mark S; Smith, Loren E; Kon, Valentina; Davies, Sean S; Linton, MacRae F

Huang, Jiansheng; Yancey, Patricia G; Tao, Huan; Borja, Mark S; Smith, Loren E; Kon, Valentina; Davies, Sean S; Linton, MacRae F.

Afiliación

Huang J; Department of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Yancey PG; Department of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Tao H; Department of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Borja MS; Department of Chemistry & Biochemistry, California State University East Bay, Hayward, CA 94542, USA.
Smith LE; Department of Anesthesiology, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Kon V; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN 37232, USA.
Davies SS; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Linton MF; Department of Medicine, Division of Cardiovascular Medicine, Atherosclerosis Research Unit, Vanderbilt University Medical Center, Nashville, TN 37232, USA.

Nutrients ; 12(7)2020 Jun 30.

Article en En | MEDLINE | ID: mdl-32629758

Asunto(s)

Arildialquilfosfatasa/sangre; Depuradores de Radicales Libres/farmacología; Hipercolesterolemia/tratamiento farmacológico; Lipoproteínas HDL/sangre; Oxidación-Reducción/efectos de los fármacos; Transportador 1 de Casete de Unión a ATP/sangre; Animales; Antiinflamatorios/farmacología; Apolipoproteína A-I/sangre; Bencilaminas/farmacología; Modelos Animales de Enfermedad; Humanos; Hipercolesterolemia/sangre; Hiperlipoproteinemia Tipo II/sangre; Hiperlipoproteinemia Tipo II/tratamiento farmacológico; Macrófagos/metabolismo; Malondialdehído/sangre; Ratones; Ratones Endogámicos C57BL; Peroxidasa/sangre; Piridoxina/farmacología

Palabras clave

cholesterol efflux; familial hypercholesterolemia; high-density lipoprotein (HDL), malondialdehyde (MDA), reactive dicarbonyl scavengers; inflammation; macrophages

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Oxidación-Reducción / Depuradores de Radicales Libres / Arildialquilfosfatasa / Hipercolesterolemia / Lipoproteínas HDL Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar en Google