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Voriconazole topical cream formulation: evidence for stability and antifungal activity.
Bouchand, Camille; Nguyen, David; Secretan, Philippe-Henri; Vidal, Fabrice; Guery, Romain; Auvity, Sylvain; Cohen, Jeremie F; Lanternier, Fanny; Lortholary, Olivier; Cisternino, Salvatore; Schlatter, Joël.
Afiliación
  • Bouchand C; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.
  • Nguyen D; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.
  • Secretan PH; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.
  • Vidal F; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France.
  • Guery R; Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France.
  • Auvity S; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France; Inserm UMR-S 1144, Université Paris Descartes, Paris, France.
  • Cohen JF; Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France.
  • Lanternier F; Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.
  • Lortholary O; Paris Descartes University, Infectious Diseases and Tropical Medicine Department, Necker-Enfants Malades Hospital, AP-HP, IHU Imagine, Paris, France; Institut Pasteur, National Reference Center for Invasive Mycoses and Antifungals, Molecular Mycology Unit, CNRS UMR2000, Paris, France.
  • Cisternino S; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France; Inserm UMR-S 1144, Université Paris Descartes, Paris, France.
  • Schlatter J; Department of Pharmacy, Necker - Enfants Malades Hospital, AP-HP, Paris, France. Electronic address: joel.schlatter@aphp.fr.
Int J Antimicrob Agents ; 56(3): 106083, 2020 Sep.
Article en En | MEDLINE | ID: mdl-32659465
ABSTRACT
Systemic use of voriconazole (VCZ) might be restricted by adverse events, such as hepatotoxicity and neurotoxicity, or drug-drug interactions. Topical VCZ application to skin may help to treat local infection more effectively and limit unwanted whole-body exposure. Topical VCZ cream was stable for 90 days when refrigerated. A patient with cutaneous Fusarium solani infection on his right forearm was successfully treated with topical 1% VCZ cream after failure of oral VCZ treatment.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fusariosis / Voriconazol / Fusarium / Antifúngicos Límite: Adult / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fusariosis / Voriconazol / Fusarium / Antifúngicos Límite: Adult / Humans / Male Idioma: En Año: 2020 Tipo del documento: Article