Detection of proteins associated with the pyroptosis signaling pathway in breast cancer tissues and their significance.

ABSTRACT

OBJECTIVE: To study the expression of pyroptosis signaling pathway related proteins in breast cancer tissues and paracancer tissues, analyze their relationship with breast cancer clinicopathologic features, and explore their relationship to prognosis. METHODS: Immunohistochemistry ElivisionTM plus was used to detect the expression of caspase-1, IL-1ß and Gasdermin-D (GSDMD) in 108 cases of breast cancer and 23 cases of benign lesions adjacent to breast cancer. RESULTS: Using 108 cases of breast cancer and 23 cases of para-cancerous benign tissues, the pyroptosis signaling pathway effector proteins caspase-1, IL-1ß, and GSDMD were positively correlated with each other. The higher the expression level, the lower the histophologic grade of breast cancer, the smaller the tumor size, the lower the clinical stage, the lower the possibility of lymph node metastasis, the lower the risk of death, and the better the prognosis. CONCLUSIONS: Pyroptosis signaling pathway effectors caspase-1, IL-1ß and GSDMD expression may play an important role in the invasion, metastasis, and prognosis of breast cancer.