Triterpenoids isolated from Jatropha macrantha (Müll. Arg.) inhibit the NF-κB and HIF-1α pathways in tumour cells.
Nat Prod Res
; 35(24): 5843-5847, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-32691666
ABSTRACT
Activity-guided fractionations of Jatropha macrantha Müll. Arg. led to the isolation of pomolic acid (1) and euscaphic acid (2). The potential for inhibition against NF-κB and HIF-1α production of these two compounds was tested in different tumour cell lines. Compounds 1 and 2 showed an inhibitory activity of HIF-1α in the SK-MEL-28 (IC50=3.01 ± 0.02 µM and 3.78 ± 0.02 µM), A549 (IC50=9.97 ± 0.01 µM and 10.25 ± 0.01 µM) and U-373 MG (IC50=6.34 ± 0.02 µM and 8.85 ± 0.02 µM) cell lines. In addition, compounds 1 and 2 showed an inhibitory activity on NF-κB in SK-MEL-28 (IC50=1.05 ± 0.02 µM and 2.71 ± 0.01 µM), A549 (IC50=3.63 ± 0.01 µM and 3.73 ± 0.02 µM) and U-373 MG (IC50=2.55 ± 0.02 µM and 3.39 ± 0.01 µM) cell lines. This is the first report that isolates these compounds from J. macrantha and tests their antitumor potential.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triterpenos
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FN-kappa B
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Jatropha
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Subunidad alfa del Factor 1 Inducible por Hipoxia
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Antineoplásicos Fitogénicos
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article