A targeted metabolomic profiling of plasma acylcarnitines in nonalcoholic fatty liver disease.
Eur Rev Med Pharmacol Sci
; 24(13): 7433-7441, 2020 07.
Article
en En
| MEDLINE
| ID: mdl-32706083
ABSTRACT
OBJECTIVE:
Nonalcoholic fatty liver disease (NAFLD) has become a common liver disorder caused by lipid accumulation and insulin resistance (IR). Acylcarnitines have become a new biomarker of IR. However, their roles in NAFLD are still poorly studied. Thus, we performed a targeted metabolomic analysis to study the level of plasma acylcarnitines in patients with NAFLD. MATERIALS ANDMETHODS:
The levels of 34 plasma acylcarnitines were measured by a targeted metabolomic approach in NAFLD patients (n = 50) and in healthy control subjects (n = 50) by liquid chromatography-tandem mass spectrometry. Detailed demographic and clinical characteristics of all subjects were also analyzed.RESULTS:
The clinical presentation of IR was identified in the NAFLD group but not in the healthy control group. Significant differences were found in the levels of several short-, medium- and long-chain acylcarnitines. A high degree of correlation (r>0.7) was found between even-numbered-carbon long-chain acylcarnitines in NAFLD patients. The area under the receiver operator characteristic of long-chain acylcarnitines, especially C20 (AUC=0.952), C161 (AUC=0.949) and C141OH (AUC=0.944) acylcarnitines, was greater in NAFLD patients than in healthy control subjects.CONCLUSIONS:
The accumulation and disorders of acylcarnitines are associated with NAFLD. A positive correlation between even-numbered-carbon long-chain acylcarnitines was found, and these even-numbered-carbon long-chain acylcarnitines. could be used as potential novel screening markers for nonalcoholic fatty liver disease.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Carnitina
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Metaboloma
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Metabolómica
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Enfermedad del Hígado Graso no Alcohólico
Tipo de estudio:
Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Año:
2020
Tipo del documento:
Article