Celecoxib combined with salirasib strongly inhibits pancreatic cancer cells in 2D and 3D cultures.

Li, Dongli; Ma, Yuran; Liu, Wenfeng; Ren, Xiang; Chen, Min; Xu, Xuetao; Sheng, Zhaojun; Zhang, Kun; Zhou, Renping; Goodin, Susan; Zheng, Xi

Li, Dongli; Ma, Yuran; Liu, Wenfeng; Ren, Xiang; Chen, Min; Xu, Xuetao; Sheng, Zhaojun; Zhang, Kun; Zhou, Renping; Goodin, Susan; Zheng, Xi.

Afiliación

Li D; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Ma Y; International Healthcare Innovation Institute (Jiangmen), Jiangmen city, Guangdong Province 529020, China.
Liu W; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Ren X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Chen M; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Xu X; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Sheng Z; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Zhang K; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Zhou R; School of Biotechnology and Health Sciences, Wuyi University, Jiangmen city, 529020, China.
Goodin S; International Healthcare Innovation Institute (Jiangmen), Jiangmen city, Guangdong Province 529020, China.
Zheng X; Department of Chemical Biology, Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, Piscataway, NJ 08854, USA.

Int J Med Sci ; 17(12): 1795-1802, 2020.

Article en En | MEDLINE | ID: mdl-32714082

Asunto(s)

Celecoxib/farmacología; Farnesol/análogos & derivados; Neoplasias Pancreáticas/tratamiento farmacológico; Proteínas Proto-Oncogénicas c-akt/genética; Proteínas Proto-Oncogénicas c-bcl-2/genética; Salicilatos/farmacología; Protocolos de Quimioterapia Combinada Antineoplásica/farmacología; Apoptosis/efectos de los fármacos; Caspasa 3/genética; Línea Celular Tumoral; Proliferación Celular/efectos de los fármacos; Supervivencia Celular/efectos de los fármacos; Farnesol/farmacología; Regulación Neoplásica de la Expresión Génica/efectos de los fármacos; Humanos; FN-kappa B/genética; Neoplasias Pancreáticas/genética; Neoplasias Pancreáticas/patología; Transducción de Señal

Palabras clave

3D cultures; NF-κB.; Pancreatic cancer; celecoxib; salirasib

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Neoplasias Pancreáticas / Salicilatos / Proteínas Proto-Oncogénicas c-bcl-2 / Proteínas Proto-Oncogénicas c-akt / Farnesol / Celecoxib Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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