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Discovery of novel histone lysine methyltransferase G9a/GLP (EHMT2/1) inhibitors: Design, synthesis, and structure-activity relationships of 2,4-diamino-6-methylpyrimidines.
Katayama, Katsushi; Ishii, Ken; Tsuda, Eisuke; Yotsumoto, Keiichi; Hiramoto, Kumiko; Suzuki, Makoto; Yasumatsu, Isao; Igarashi, Wataru; Torihata, Munefumi; Ishiyama, Takashi; Katagiri, Takahiro.
Afiliación
  • Katayama K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address: katayama.katsushi.ne@daiichisankyo.co.jp.
  • Ishii K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Tsuda E; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Yotsumoto K; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Hiramoto K; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.
  • Suzuki M; Daiichi Sankyo RD Novare Co., Ltd., 1-16-13 Kitakasai, Edogawa-ku, Tokyo 134-8630, Japan.
  • Yasumatsu I; Daiichi Sankyo RD Novare Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Igarashi W; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Torihata M; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Ishiyama T; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan.
  • Katagiri T; R&D Division, Daiichi Sankyo Co., Ltd., 1-2-58 Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. Electronic address: katagiri.takahiro.k6@daiichisankyo.co.jp.
Bioorg Med Chem Lett ; 30(20): 127475, 2020 10 15.
Article en En | MEDLINE | ID: mdl-32781218
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / N-Metiltransferasa de Histona-Lisina / Inhibidores Enzimáticos / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pirimidinas / N-Metiltransferasa de Histona-Lisina / Inhibidores Enzimáticos / Descubrimiento de Drogas Límite: Animals / Humans Idioma: En Año: 2020 Tipo del documento: Article