Radiation Therapy and the In Situ Vaccination Approach.
Int J Radiat Oncol Biol Phys
; 108(4): 891-898, 2020 11 15.
Article
en En
| MEDLINE
| ID: mdl-32800803
ABSTRACT
During the past century, from the advent of preclinical modeling to the establishment of clinical trials, the hypothesis that host defenses regulate tumor growth (posited and refined by leaders in the field of cancer immunity) has become accepted as a scientific pillar in oncology. Since the turn of the millennium, a search has been under way for the best therapeutic approach to reprogram the immune system to recognize tumor cells that have undergone "immune escape." This quest has led some to question conventional scientific views of tumor cell kill, including the role of host immunity in patients treated with radiation therapy. In the last two decades, evidence has accumulated that radiation therapy can effectively convert a potentially lethal cancer into an in situ personalized vaccine. Herein, we review the underlying mechanisms and maneuvers responsible for in situ vaccine production.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Escape del Tumor
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Vacunas contra el Cáncer
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Vigilancia Inmunológica
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Antígenos de Neoplasias
/
Neoplasias
Tipo de estudio:
Etiology_studies
Límite:
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article