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Targeting a helix-in-groove interaction between E1 and E2 blocks ubiquitin transfer.
Cathcart, Ann M; Bird, Gregory H; Wales, Thomas E; Herce, Henry D; Harvey, Edward P; Hauseman, Zachary J; Newman, Catherine E; Adhikary, Utsarga; Prew, Michelle S; Oo, Tun; Lee, Susan; Engen, John R; Walensky, Loren D.
Afiliación
  • Cathcart AM; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Bird GH; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Wales TE; The Harvard Graduate Program in Biophysics, Harvard University, Boston, MA, USA.
  • Herce HD; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Harvey EP; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Hauseman ZJ; Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA, USA.
  • Newman CE; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Adhikary U; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Prew MS; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Oo T; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Lee S; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Engen JR; Linde Program in Cancer Chemical Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
  • Walensky LD; Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA, USA.
Nat Chem Biol ; 16(11): 1218-1226, 2020 11.
Article en En | MEDLINE | ID: mdl-32807965
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ubiquitina / Enzimas Activadoras de Ubiquitina / Complejo de la Endopetidasa Proteasomal Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Ubiquitina / Enzimas Activadoras de Ubiquitina / Complejo de la Endopetidasa Proteasomal Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article