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Next-Generation Surrogate Wnts Support Organoid Growth and Deconvolute Frizzled Pleiotropy In Vivo.
Miao, Yi; Ha, Andrew; de Lau, Wim; Yuki, Kanako; Santos, António J M; You, Changjiang; Geurts, Maarten H; Puschhof, Jens; Pleguezuelos-Manzano, Cayetano; Peng, Weng Chuan; Senlice, Ramazan; Piani, Carol; Buikema, Jan W; Gbenedio, Oghenekevwe M; Vallon, Mario; Yuan, Jenny; de Haan, Sanne; Hemrika, Wieger; Rösch, Kathrin; Dang, Luke T; Baker, David; Ott, Melanie; Depeille, Philippe; Wu, Sean M; Drost, Jarno; Nusse, Roeland; Roose, Jeroen P; Piehler, Jacob; Boj, Sylvia F; Janda, Claudia Y; Clevers, Hans; Kuo, Calvin J; Garcia, K Christopher.
Afiliación
  • Miao Y; Department of Molecular and Cellular Physiology, Department of Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Ha A; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Biology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • de Lau W; Oncode Institute, Hubrecht Institute, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Yuki K; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Santos AJM; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • You C; Division of Biophysics, Department of Biology, University of Osnabrück, 49076 Osnabrück, Germany.
  • Geurts MH; Oncode Institute, Hubrecht Institute, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Puschhof J; Oncode Institute, Hubrecht Institute, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Pleguezuelos-Manzano C; Oncode Institute, Hubrecht Institute, University Medical Centre Utrecht, Utrecht, the Netherlands.
  • Peng WC; Howard Hughes Medical Institute, Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Senlice R; Foundation Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands.
  • Piani C; Foundation Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands.
  • Buikema JW; Department of Cardiology, University Medical Center Utrecht & Utrecht Regenerative Medicine Center, Utrecht University, 3508 GA Utrecht, the Netherlands.
  • Gbenedio OM; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
  • Vallon M; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Yuan J; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • de Haan S; Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Hemrika W; U-Protein Express BV, Yalelaan 62, 3584 CM Utrecht, the Netherlands.
  • Rösch K; Gladstone Institutes and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Dang LT; Department of Biochemistry, Institute for Protein Design and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA.
  • Baker D; Department of Biochemistry, Institute for Protein Design and Howard Hughes Medical Institute, University of Washington, Seattle, WA 98105, USA.
  • Ott M; Gladstone Institutes and Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.
  • Depeille P; Department of Cardiology, University Medical Center Utrecht & Utrecht Regenerative Medicine Center, Utrecht University, 3508 GA Utrecht, the Netherlands.
  • Wu SM; Division of Cardiovascular Medicine, Department of Medicine, Cardiovascular Institute and Institute of Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Drost J; Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Nusse R; Howard Hughes Medical Institute, Department of Developmental Biology, Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Roose JP; Department of Anatomy, University of California, San Francisco, San Francisco, CA, USA.
  • Piehler J; Division of Biophysics, Department of Biology, University of Osnabrück, 49076 Osnabrück, Germany.
  • Boj SF; Foundation Hubrecht Organoid Technology (HUB), Utrecht, the Netherlands.
  • Janda CY; Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
  • Clevers H; Oncode Institute, Hubrecht Institute, University Medical Centre Utrecht, Utrecht, the Netherlands; Oncode Institute, Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, the Netherlands.
  • Kuo CJ; Department of Medicine, Division of Hematology, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Garcia KC; Department of Molecular and Cellular Physiology, Department of Structural Biology, Howard Hughes Medical Institute, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: kcgarcia@stanford.edu.
Cell Stem Cell ; 27(5): 840-851.e6, 2020 11 05.
Article en En | MEDLINE | ID: mdl-32818433

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Organoides / Receptores Frizzled Idioma: En Año: 2020 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Organoides / Receptores Frizzled Idioma: En Año: 2020 Tipo del documento: Article