Development and Validation of a High Sensitivity Assay for Measuring p217â+âtau in Cerebrospinal Fluid.

Triana-Baltzer, Gallen; Van Kolen, Kristof; Theunis, Clara; Moughadam, Setareh; Slemmon, Randy; Mercken, Marc; Galpern, Wendy; Sun, Hong; Kolb, Hartmuth

Development and Validation of a High Sensitivity Assay for Measuring p217â+âtau in Cerebrospinal Fluid.

Triana-Baltzer, Gallen; Van Kolen, Kristof; Theunis, Clara; Moughadam, Setareh; Slemmon, Randy; Mercken, Marc; Galpern, Wendy; Sun, Hong; Kolb, Hartmuth.

Afiliación

Triana-Baltzer G; Neuroscience Biomarkers, Janssen Research & Development, La Jolla, CA, USA.
Van Kolen K; Neuroscience Department, Janssen Research and Development, Beerse, Belgium.
Theunis C; Neuroscience Department, Janssen Research and Development, Beerse, Belgium.
Moughadam S; Neuroscience Biomarkers, Janssen Research & Development, La Jolla, CA, USA.
Slemmon R; Neuroscience Biomarkers, Janssen Research & Development, La Jolla, CA, USA.
Mercken M; Neuroscience Department, Janssen Research and Development, Beerse, Belgium.
Galpern W; Neuroscience Experimental Medicine, Janssen Research & Development, Titusville, NJ, USA.
Sun H; Neuroscience Clinical Development, Janssen Research & Development, Titusville, NJ, USA.
Kolb H; Neuroscience Biomarkers, Janssen Research & Development, La Jolla, CA, USA.

J Alzheimers Dis ; 77(4): 1417-1430, 2020.

Article en En | MEDLINE | ID: mdl-32831201

Asunto(s)

Fragmentos de Péptidos/análisis; Fragmentos de Péptidos/metabolismo; Proteínas tau/análisis; Proteínas tau/metabolismo; Anciano; Enfermedad de Alzheimer/líquido cefalorraquídeo; Enfermedad de Alzheimer/diagnóstico; Biomarcadores/líquido cefalorraquídeo; Estudios de Cohortes; Ensayo de Inmunoadsorción Enzimática/métodos; Ensayo de Inmunoadsorción Enzimática/normas; Femenino; Humanos; Masculino; Persona de Mediana Edad; Reproducibilidad de los Resultados

Palabras clave

Alzheimer's disease; biomarker; cerebrospinal fluid; p212; p217; phosphorylation; tau

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Proteínas tau Tipo de estudio: Diagnostic_studies / Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Año: 2020 Tipo del documento: Article

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