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Weak binding to the A2RE RNA rigidifies hnRNPA2 RRMs and reduces liquid-liquid phase separation and aggregation.
Ryan, Veronica H; Watters, Scott; Amaya, Joshua; Khatiwada, Balabhadra; Venditti, Vincenzo; Naik, Mandar T; Fawzi, Nicolas L.
Afiliación
  • Ryan VH; Neuroscience Graduate Program, Brown University, Providence, RI 02912, USA.
  • Watters S; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
  • Amaya J; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
  • Khatiwada B; Department of Chemistry, Iowa State University, Ames, IA, USA.
  • Venditti V; Department of Chemistry, Iowa State University, Ames, IA, USA.
  • Naik MT; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
  • Fawzi NL; Department of Molecular Pharmacology, Physiology, and Biotechnology, Brown University, Providence, RI 02912, USA.
Nucleic Acids Res ; 48(18): 10542-10554, 2020 10 09.
Article en En | MEDLINE | ID: mdl-32870271
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al ARN / Elementos de Respuesta / Ribonucleoproteína Heterogénea-Nuclear Grupo A-B / Motivo de Reconocimiento de ARN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Proteínas de Unión al ARN / Elementos de Respuesta / Ribonucleoproteína Heterogénea-Nuclear Grupo A-B / Motivo de Reconocimiento de ARN Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article