Focused Ultrasound for Immunomodulation of the Tumor Microenvironment.
J Immunol
; 205(9): 2327-2341, 2020 11 01.
Article
en En
| MEDLINE
| ID: mdl-33077668
ABSTRACT
Focused ultrasound (FUS) has recently emerged as a modulator of the tumor microenvironment, paving the way for FUS to become a safe yet formidable cancer treatment option. Several mechanisms have been proposed for the role of FUS in facilitating immune responses and overcoming drug delivery barriers. However, with the wide variety of FUS parameters used in diverse tumor types, it is challenging to pinpoint FUS specifications that may elicit the desired antitumor response. To clarify FUS bioeffects, we summarize four mechanisms of action, including thermal ablation, hyperthermia/thermal stress, mechanical perturbation, and histotripsy, each inducing unique vascular and immunological effects. Notable tumor responses to FUS include enhanced vascular permeability, increased T cell infiltration, and tumor growth suppression. In this review, we have categorized and reviewed recent methods of using therapeutic ultrasound to elicit an antitumor immune response with examples that reveal specific solutions and challenges in this new research area.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Inmunomodulación
/
Microambiente Tumoral
/
Neoplasias
Límite:
Animals
/
Humans
Idioma:
En
Año:
2020
Tipo del documento:
Article