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LRP1 polymorphisms associated with warfarin stable dose in Chinese patients: a stepwise conditional analysis.
Li, Dan; Zhu, Hong; Luo, Zhi-Ying; Chen, Yi; Song, Guo-Bao; Zhou, Xin-Ming; Yan, Han; Zhou, Hong-Hao; Zhang, Wei; Li, Xi.
Afiliación
  • Li D; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China.
  • Zhu H; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China.
  • Luo ZY; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, PR China.
  • Chen Y; Department of Cardiovascular Surgery, Xiangya Hospital, Central South University, Changsha, 410008, PR China.
  • Song GB; Department of Pharmacy, The Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
  • Zhou XM; Department of Clinical Pharmacology, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China.
  • Yan H; Department of Neurosurgery, Xiangya Hospital, Central South University, 87 Xiangya Road, Changsha, Hunan, 410008, PR China.
  • Zhou HH; Institute of Clinical Pharmacology, Central South University; Hunan Key Laboratory of Pharmacogenetics, Changsha, 410078, PR China.
  • Zhang W; Department of Cardio-Thoracic Surgery, the Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
  • Li X; Department of Cardio-Thoracic Surgery, the Second Xiangya Hospital, Central South University, Changsha, 410011, PR China.
Pharmacogenomics ; 21(16): 1169-1178, 2020 11.
Article en En | MEDLINE | ID: mdl-33094665
ABSTRACT

Aim:

The aim of this study was to investigate whether variability in warfarin stable dose (WSD) could be influenced by vitamin K-related polymorphisms in patients with heart valve replacement. Patients &

methods:

Twenty-nine vitamin K-related SNPs in 208 patients who initially took warfarin and achieved WSD were genotyped.

Results:

After conducting conditional analysis for both VKORC1 -1639G>A and CYP2C9*3, LRP1 rs1800139 and LRP1 rs1800154 were significantly associated with WSD (p = 0.007 and p = 0.015, respectively). Multivariate analysis showed that LRP1 rs1800139 accounted for 5.9% WSD variability.

Conclusion:

Our results suggest that a novel vitamin K-related gene, LRP1, exerts a relevant influence on WSD, independent of VKORC1 -1639G>A and CYP2C9*3.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Warfarina / Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Anticoagulantes Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Año: 2020 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Warfarina / Proteína 1 Relacionada con Receptor de Lipoproteína de Baja Densidad / Anticoagulantes Tipo de estudio: Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Año: 2020 Tipo del documento: Article