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Detection and impact of hysteresis when evaluating a drug's QTc effect using concentration-QTc analysis.
Ferber, Georg; Darpo, Borje; Garnett, Christine; Huang, Dalong; Marathe, Dhananjay D; Sun, Yaning; Liu, Jiang.
Afiliación
  • Ferber G; Statistik Georg Ferber GmbH, Cagliostrostrasse 14, 4125, Riehen, Switzerland. Statistik.Georg.Ferber@bluewin.ch.
  • Darpo B; ERT, Rochester, NY, USA.
  • Garnett C; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Huang D; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Marathe DD; Merck & Co., Inc., Rahway, NJ, USA.
  • Sun Y; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
  • Liu J; Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
J Pharmacokinet Pharmacodyn ; 48(2): 187-202, 2021 04.
Article en En | MEDLINE | ID: mdl-33118135
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de QT Prolongado / Electrocardiografía / Modelos Biológicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Síndrome de QT Prolongado / Electrocardiografía / Modelos Biológicos Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article