Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-&#954;B-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.

Hassanein, Emad H M; Ali, Fares E M; Kozman, Magy R; Abd El-Ghafar, Omnia A M

Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.

Hassanein, Emad H M; Ali, Fares E M; Kozman, Magy R; Abd El-Ghafar, Omnia A M.

Afiliación

Hassanein EHM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt.
Ali FEM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt. Faresali@azhar.edu.eg.
Kozman MR; Clinical Pharmacology Department, Faculty of Pharmacy, Misr University for Science and Technology, Cairo, Egypt.
Abd El-Ghafar OAM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Nahda University, Beni-Suef, Egypt.

Environ Sci Pollut Res Int ; 28(9): 11558-11571, 2021 Mar.

Article en En | MEDLINE | ID: mdl-33128149

Asunto(s)

Gentamicinas; FN-kappa B; Animales; Gentamicinas/toxicidad; Riñón/metabolismo; FN-kappa B/metabolismo; Ratas; Transducción de Señal; Receptor Toll-Like 4; Umbeliferonas/farmacología

Palabras clave

Gentamicin; JAK1/STAT-3; Nephrotoxicity; TLR-4/NF-κB-p65/NLRP-3; Umbelliferone

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gentamicinas / FN-kappa B Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

Texto completo

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gentamicinas / FN-kappa B Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article