Centriole length control.
Curr Opin Struct Biol
; 66: 89-95, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33220554
ABSTRACT
Centrioles are microtubule-based structures involved in cell division and ciliogenesis. Centriole formation is a highly regulated cellular process and aberrations in centriole structure, size or numbers have implications in multiple human pathologies. In this review, we propose that the proteins that control centriole length can be subdivided into two classes based on their antagonistic activities on centriolar microtubules, which we refer to as 'centriole elongation activators' (CEAs) and 'centriole elongation inhibitors' (CEIs). We discuss and illustrate the structure-function relationship of CEAs and CEIs as well as their interaction networks. Based on our current knowledge, we formulate some outstanding open questions in the field and present possible routes for future studies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Centriolos
/
Microtúbulos
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article