Infiltrating T-cell markers in cervical carcinogenesis: a systematic review and meta-analysis.
Br J Cancer
; 124(4): 831-841, 2021 02.
Article
en En
| MEDLINE
| ID: mdl-33257839
ABSTRACT
BACKGROUND:
The host adaptive immune response helps determine which cervical HPV infections persist and progress to precancer and cancer, and systematic characterisation of T-cell infiltration would help inform key steps in cervical carcinogenesis.METHODS:
A systematic review and meta-analysis were conducted of infiltrating T-cells in normal cervix, low-grade lesions, high-grade lesions, and invasive cancers including epithelial, stromal, and total tissue and the following markers CD3, CD4, CD8, FoxP3, CD25, and the CD4CD8 ratio. An additional qualitative review summarised longitudinal data on associations between infiltrating T-cells and cervical disease persistence, regression, progression, or prognosis.RESULTS:
There were fewer CD3+, CD4+, and CD8+ cells in cervical lesions and more cells in cancers compared to normal epithelium. FoxP3 and CD25+ regulatory T-cell infiltration is high in persistent and precancerous lesions, and longitudinal data show improved outcomes with lower regulatory T-cell levels.CONCLUSIONS:
Successful immune evasion may reduce T-cell infiltration in HPV infected and precancerous epithelium, while invasive cancers are highly immunogenic, and regulatory T-cell infiltration increases with cervical disease progression. Understanding these factors may have prognostic value and could aid in novel treatment development and clinical guidelines, but published data are highly heterogeneous and leave important gaps to be filled by future studies.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Linfocitos T
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Neoplasias del Cuello Uterino
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Linfocitos Infiltrantes de Tumor
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Infecciones por Papillomavirus
Tipo de estudio:
Guideline
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Prognostic_studies
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Qualitative_research
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Systematic_reviews
Límite:
Female
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article