Nucleic Acid-Based Technologies Targeting Coronaviruses.
Trends Biochem Sci
; 46(5): 351-365, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33309323
ABSTRACT
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is currently creating a global health emergency. This crisis is driving a worldwide effort to develop effective vaccines, prophylactics, and therapeutics. Nucleic acid (NA)-based treatments hold great potential to combat outbreaks of coronaviruses (CoVs) due to their rapid development, high target specificity, and the capacity to increase druggability. Here, we review key anti-CoV NA-based technologies, including antisense oligonucleotides (ASOs), siRNAs, RNA-targeting clustered regularly interspaced short palindromic repeats-CRISPR-associated protein (CRISPR-Cas), and mRNA vaccines, and discuss improved delivery methods and combination therapies with other antiviral drugs.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
ARN Mensajero
/
ARN Viral
/
Sistemas CRISPR-Cas
/
Vacunas contra la COVID-19
/
SARS-CoV-2
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article