Identification of Key Receptor Residues Discriminating Human Chorionic Gonadotropin (hCG)- and Luteinizing Hormone (LH)-Specific Signaling.

Lazzaretti, Clara; Secco, Valentina; Paradiso, Elia; Sperduti, Samantha; Rutz, Claudia; Kreuchwig, Annika; Krause, Gerd; Simoni, Manuela; Casarini, Livio

Lazzaretti, Clara; Secco, Valentina; Paradiso, Elia; Sperduti, Samantha; Rutz, Claudia; Kreuchwig, Annika; Krause, Gerd; Simoni, Manuela; Casarini, Livio.

Afiliación

Lazzaretti C; Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Secco V; International PhD School in Clinical and Experimental Medicine (CEM), University of Modena and Reggio Emilia, 41125 Modena, Italy.
Paradiso E; Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Sperduti S; Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Rutz C; International PhD School in Clinical and Experimental Medicine (CEM), University of Modena and Reggio Emilia, 41125 Modena, Italy.
Kreuchwig A; Unit of Endocrinology, Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, 41126 Modena, Italy.
Krause G; Center for Genomic Research, University of Modena and Reggio Emilia, Via G. Campi 287, 41125 Modena, Italy.
Simoni M; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.
Casarini L; Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), 13125 Berlin, Germany.

Int J Mol Sci ; 22(1)2020 Dec 25.

Article en En | MEDLINE | ID: mdl-33375708

Asunto(s)

Aminoácidos/química; Sitios de Unión; Receptores de HL/química; Receptores de HL/metabolismo; Secuencia de Aminoácidos; Gonadotropina Coriónica/metabolismo; AMP Cíclico/metabolismo; Células HEK293; Humanos; Cinética; Hormona Luteinizante/metabolismo; Proteína Quinasa 1 Activada por Mitógenos; Proteína Quinasa 3 Activada por Mitógenos; Mutación; Fosforilación; Unión Proteica; Dominios y Motivos de Interacción de Proteínas; Receptores de HL/genética; Transducción de Señal

Palabras clave

ERK1/2; LH/hCG receptor (LHCGR); cAMP; human chorionic gonadotropin (hCG); luteinizing hormone (LH); mutation

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Sitios de Unión / Receptores de HL / Aminoácidos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Qualitative_research Límite: Humans Idioma: En Año: 2020 Tipo del documento: Article

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