Electrostatic-Mediated Affinity Tuning of Lysostaphin Accelerates Bacterial Lysis Kinetics and Enhances <i>In Vivo</i> Efficacy.

Zhao, Hongliang; Eszterhas, Susan; Furlon, Jacob; Cheng, Hao; Griswold, Karl E

Electrostatic-Mediated Affinity Tuning of Lysostaphin Accelerates Bacterial Lysis Kinetics and Enhances In Vivo Efficacy.

Zhao, Hongliang; Eszterhas, Susan; Furlon, Jacob; Cheng, Hao; Griswold, Karl E.

Afiliación

Zhao H; Thayer School of Engineering, Dartmouth, Hanover, New Hampshire, USA.
Eszterhas S; Thayer School of Engineering, Dartmouth, Hanover, New Hampshire, USA.
Furlon J; Department of Microbiology and Immunology, Dartmouth, Hanover, New Hampshire, USA.
Cheng H; Thayer School of Engineering, Dartmouth, Hanover, New Hampshire, USA.
Griswold KE; Lyticon LLC, Lebanon, New Hampshire, USA.

Antimicrob Agents Chemother ; 65(4)2021 03 18.

Article en En | MEDLINE | ID: mdl-33468459

Asunto(s)

Lisostafina; Staphylococcus aureus Resistente a Meticilina; Antibacterianos/farmacología; Antibacterianos/uso terapéutico; Cinética; Lisostafina/metabolismo; Lisostafina/farmacología; Staphylococcus aureus Resistente a Meticilina/metabolismo; Electricidad Estática

Palabras clave

MIC; MRSA; affinity tuning; antibacterial lysin; electrostatic interaction; enzyme kinetics; in vivo efficacy; lysostaphin; minimal inhibitory concentration; protein engineering

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Staphylococcus aureus Resistente a Meticilina / Lisostafina Idioma: En Año: 2021 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Staphylococcus aureus Resistente a Meticilina / Lisostafina Idioma: En Año: 2021 Tipo del documento: Article