Adherence to subcutaneous biological therapies in patients with inflammatory rheumatic diseases and inflammatory bowel disease: a systematic review.
Immunotherapy
; 13(5): 433-458, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33557600
ABSTRACT
Aim:
To assess adherence to subcutaneous biologicals in adults with inflammatory rheumatic diseases or inflammatory bowel disease and evaluate factors possibly associated with adherence. Materials &methods:
Systematic searches were conducted of main databases from January 2000 to June 2019.Results:
41 articles (32 full papers and nine abstracts) were included in the review. Among studies which used a medication possession ratio threshold of ≥80% as the end point, adherence varied from 28.8 to 89.4%. Possible predictors of adherence were older age, professional or family member support, belief in medication necessity, lower concerns about medication and monthly versus weekly administration.Conclusion:
Considerable variability in adherence rates across published studies reflects study heterogeneity and the absence of a 'gold standard' to measure adherence.Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Terapia Biológica
/
Enfermedades Inflamatorias del Intestino
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Enfermedades Reumáticas
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Cumplimiento de la Medicación
Tipo de estudio:
Prognostic_studies
/
Systematic_reviews
Límite:
Adult
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Female
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Humans
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Male
Idioma:
En
Año:
2021
Tipo del documento:
Article