Atherosclerosis and Inflammatory Bowel Disease-Shared Pathogenesis and Implications for Treatment.
Angiology
; 72(4): 303-314, 2021 04.
Article
en En
| MEDLINE
| ID: mdl-33601945
ABSTRACT
Atherosclerosis and inflammatory bowel disease (IBD) are often regarded as 2 distinct entities. The commonest manifestation of atherosclerosis is ischemic heart disease (IHD), and an association between IHD and IBD has been reported. Atherosclerosis and IBD share common pathophysiological mechanisms in terms of their genetics, immunology, and contributing environmental factors. Factors associated with atherosclerosis are implicated in the development of IBD and vice versa. Therefore, treatments targeting the common pathophysiology pathways may be effective in both conditions. The current review considers the pathophysiological pathways that are shared between the 2 conditions and discusses the implications for treatment and research.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Inflamatorias del Intestino
/
Polimorfismo de Nucleótido Simple
/
Aterosclerosis
/
Inmunidad Adaptativa
/
Inmunidad Innata
/
Estilo de Vida
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Animals
/
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article