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Design and synthesis of a monocyclic derivative as a selective ACC1 inhibitor by chemical modification of biphenyl ACC1/2 dual inhibitors.
Mizojiri, Ryo; Tomita, Daisuke; Sasaki, Masako; Satoh, Yoshihiko; Yamamoto, Yukiko; Sumi, Hiroyuki; Maezaki, Hironobu.
Afiliación
  • Mizojiri R; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan. Electronic address: ryo.mizojiri@takeda.com.
  • Tomita D; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sasaki M; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Satoh Y; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Yamamoto Y; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Sumi H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
  • Maezaki H; Research, Takeda Pharmaceutical Company Limited, 26-1, Muraoka-Higashi 2-chome, Fujisawa, Kanagawa 251-8555, Japan.
Bioorg Med Chem ; 35: 116056, 2021 04 01.
Article en En | MEDLINE | ID: mdl-33607488
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Compuestos de Bencilo / Diseño de Fármacos / Inhibidores Enzimáticos / Acetamidas Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Acetil-CoA Carboxilasa / Compuestos de Bencilo / Diseño de Fármacos / Inhibidores Enzimáticos / Acetamidas Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article