Temocillin as an alternative treatment for acute bacterial cholangitis: a retrospective microbiology susceptibility-based study of 140 episodes.
Eur J Clin Microbiol Infect Dis
; 40(8): 1773-1777, 2021 Aug.
Article
en En
| MEDLINE
| ID: mdl-33609262
ABSTRACT
With rising antibiotic resistance, alternatives to carbapenems are needed for acute cholangitis (AC). Temocillin reaches high biliary concentrations with limited impact on microbiota. We retrospectively included 140 AC episodes and assessed the efficacy of temocillin using microbiology susceptibility testing from blood cultures. Considering all bacteria collected by episode, resistance to temocillin, PIP/TAZ and 3GC occurred in 27/140 (26%), 32 (22.8%) and 31 (22%) episodes, respectively (p = 0.7). After documentation, temocillin could have spared PIP/TAZ or carbapenems in 14/26 and 4/11 episodes. Temocillin may constitute an alternative treatment after microbiological documentation by sparing carbapenems and/or PIP/TAZ, but not as an empirical therapeutic option.
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Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Penicilinas
/
Infecciones Bacterianas
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Colangitis
/
Antibacterianos
Tipo de estudio:
Observational_studies
Límite:
Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article