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Antiviral Bafilomycins from a Feces-Inhabiting Streptomyces sp.
Xie, Xi; Lu, Shengsheng; Pan, Xiaoyan; Zou, Min; Li, Fangfang; Lin, Haixing; Hu, Jianan; Fan, Sheng; He, Jian.
Afiliación
  • Xie X; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • Lu S; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • Pan X; State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences, Wuhan 430071, People's Republic of China.
  • Zou M; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • Li F; Guangdong Provincial Key Laboratory of Emergency Test for Dangerous Chemicals, China National Analytical Center, Guangzhou 510070, People's Republic of China.
  • Lin H; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • Hu J; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • Fan S; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
  • He J; Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences, Southern Medical University, 1838 Guangzhou Avenue North, Guangzhou 510515, People's Republic of China.
J Nat Prod ; 84(2): 537-543, 2021 02 26.
Article en En | MEDLINE | ID: mdl-33631936
ABSTRACT
A new bafilomycin derivative (1) and another seven known bafilomycins (2-8) were isolated from feces-derived Streptomyces sp. HTL16. The structure of 1 was elucidated by 1D and 2D NMR spectroscopic analysis. Biological testing demonstrated that these bafilomycins exhibited potent antiviral activities against the influenza A and SARS-CoV-2 viruses, with IC50 values in the nanomolar range, by inhibiting the activity of endosomal ATP-driven proton pumps.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Streptomyces / ATPasas de Translocación de Protón / Macrólidos / Heces Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Antivirales / Streptomyces / ATPasas de Translocación de Protón / Macrólidos / Heces Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article