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Mutational fitness landscapes reveal genetic and structural improvement pathways for a vaccine-elicited HIV-1 broadly neutralizing antibody.
Madan, Bharat; Zhang, Baoshan; Xu, Kai; Chao, Cara W; O'Dell, Sijy; Wolfe, Jacy R; Chuang, Gwo-Yu; Fahad, Ahmed S; Geng, Hui; Kong, Rui; Louder, Mark K; Nguyen, Thuy Duong; Rawi, Reda; Schön, Arne; Sheng, Zizhang; Nimrania, Rajani; Wang, Yiran; Zhou, Tongqing; Lin, Bob C; Doria-Rose, Nicole A; Shapiro, Lawrence; Kwong, Peter D; DeKosky, Brandon J.
Afiliación
  • Madan B; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045.
  • Zhang B; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Xu K; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Chao CW; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • O'Dell S; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Wolfe JR; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045.
  • Chuang GY; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Fahad AS; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045.
  • Geng H; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Kong R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Louder MK; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Nguyen TD; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045.
  • Rawi R; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Schön A; Department of Biology, John Hopkins University, Baltimore, MD 21218.
  • Sheng Z; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027.
  • Nimrania R; Department of Pharmaceutical Chemistry, The University of Kansas, Lawrence, KS 66045.
  • Wang Y; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Zhou T; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Lin BC; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Doria-Rose NA; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Shapiro L; Vaccine Research Center, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.
  • Kwong PD; Department of Biochemistry and Molecular Biophysics, Columbia University, New York, NY 10027.
  • DeKosky BJ; Aaron Diamond AIDS Research Center, Columbia University Irving Medical Center, New York, NY 10032.
Proc Natl Acad Sci U S A ; 118(10)2021 03 09.
Article en En | MEDLINE | ID: mdl-33649208
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Anti-VIH / VIH-1 / Vacunas contra el SIDA / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Anticuerpos ampliamente neutralizantes / Mutación Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Anticuerpos Anti-VIH / VIH-1 / Vacunas contra el SIDA / Productos del Gen env del Virus de la Inmunodeficiencia Humana / Anticuerpos ampliamente neutralizantes / Mutación Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article