Prediction of dose-dependent in vivo acetylcholinesterase inhibition by profenofos in rats and humans using physiologically based kinetic (PBK) modeling-facilitated reverse dosimetry.

Omwenga, Isaac; Zhao, Shensheng; Kanja, Laetitia; Mol, Hans; Rietjens, Ivonne M C M; Louisse, Jochem

Omwenga, Isaac; Zhao, Shensheng; Kanja, Laetitia; Mol, Hans; Rietjens, Ivonne M C M; Louisse, Jochem.

Afiliación

Omwenga I; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands. isaac.omwenga@wur.nl.
Zhao S; Department of Public Health, Pharmacology and Toxicology, Faculty of Veterinary Sciences, University of Nairobi, P.O. Box 29053-00625, Nairobi, Kenya. isaac.omwenga@wur.nl.
Kanja L; Department of Animal Science, Meru University of Science and Technology, P.O. Box 972-60200, Meru, Kenya. isaac.omwenga@wur.nl.
Mol H; Division of Toxicology, Wageningen University and Research, Stippeneng 4, 6708 WE, Wageningen, The Netherlands.
Rietjens IMCM; Department of Public Health, Pharmacology and Toxicology, Faculty of Veterinary Sciences, University of Nairobi, P.O. Box 29053-00625, Nairobi, Kenya.
Louisse J; Wageningen Food Safety Research, Wageningen University and Research, Akkermaalsbos 2, 6708 WB, Wageningen, The Netherlands.

Arch Toxicol ; 95(4): 1287-1301, 2021 04.

Article en En | MEDLINE | ID: mdl-33651127

Asunto(s)

Inhibidores de la Colinesterasa/toxicidad; Modelos Biológicos; Organotiofosfatos/toxicidad; Plaguicidas/toxicidad; Acetilcolinesterasa/efectos de los fármacos; Acetilcolinesterasa/metabolismo; Animales; Inhibidores de la Colinesterasa/administración & dosificación; Simulación por Computador; Relación Dosis-Respuesta a Droga; Femenino; Humanos; Masculino; Microsomas Hepáticos/efectos de los fármacos; Microsomas Hepáticos/enzimología; Organotiofosfatos/administración & dosificación; Ratas; Ratas Sprague-Dawley; Especificidad de la Especie

Palabras clave

Acetylcholinesterase (AChE) inhibition; Novel approach method (NAM); Organophosphate pesticides (OPs); Physiologically based kinetic (PBK) modeling; Reverse dosimetry

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Plaguicidas / Organotiofosfatos / Inhibidores de la Colinesterasa / Modelos Biológicos Tipo de estudio: Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans / Male Idioma: En Año: 2021 Tipo del documento: Article

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