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Bispecific VH/Fab antibodies targeting neutralizing and non-neutralizing Spike epitopes demonstrate enhanced potency against SARS-CoV-2.
Lim, Shion A; Gramespacher, Josef A; Pance, Katarina; Rettko, Nicholas J; Solomon, Paige; Jin, Jing; Lui, Irene; Elledge, Susanna K; Liu, Jia; Bracken, Colton J; Simmons, Graham; Zhou, Xin X; Leung, Kevin K; Wells, James A.
Afiliación
  • Lim SA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Gramespacher JA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Pance K; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Rettko NJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Solomon P; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Jin J; Vitalant Research Institute and Department of Laboratory Medicine, University of California San Francisco, University of California San Francisco, California, USA.
  • Lui I; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Elledge SK; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Liu J; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Bracken CJ; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Simmons G; Vitalant Research Institute and Department of Laboratory Medicine, University of California San Francisco, University of California San Francisco, California, USA.
  • Zhou XX; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Leung KK; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
  • Wells JA; Department of Pharmaceutical Chemistry, University of California San Francisco, San Francisco, California, USA.
MAbs ; 13(1): 1893426, 2021.
Article en En | MEDLINE | ID: mdl-33666135
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos Fab de Inmunoglobulinas / Anticuerpos Biespecíficos / Anticuerpos Neutralizantes / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales / Epítopos Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos Fab de Inmunoglobulinas / Anticuerpos Biespecíficos / Anticuerpos Neutralizantes / Glicoproteína de la Espiga del Coronavirus / SARS-CoV-2 / COVID-19 / Anticuerpos Antivirales / Epítopos Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article