The association of post-operative delirium with patient-reported outcomes and mortality after lung transplantation.
Clin Transplant
; 35(5): e14275, 2021 05.
Article
en En
| MEDLINE
| ID: mdl-33682171
ABSTRACT
Post-operative delirium after lung transplantation is common. Its associations with health-related quality of life (HRQL), depression, and mortality remains unknown. In 236 lung transplant recipients, HRQL and depressive symptoms were assessed as part of a structured survey battery before and after transplantation. Surveys included the Geriatric Depressive Scale (GDS) and Short Form 12 (SF12). Delirium was assessed throughout the post-operative intensive care unit (ICU) stay with Confusion Assessment Method for ICU. Delirium and mortality data were extracted from electronic medical records. We examined associations between delirium and changes in depressive symptoms and HRQL using linear mixed effects models and association between delirium and mortality with Cox-proportional hazard models. Post-operative delirium occurred in 34 participants (14%). Delirium was associated with attenuated improvements in SF12-PCS (difference â4.0; 95%CI -7.4, -0.7) but not SF12-MCS (difference 2.2; 95%CI -0.7,5.7) or GDS (difference â0.4; 95%CI -1.5,0.7). Thirty-two participants died during the study period. Delirium was associated with increased adjusted hazard risk of mortality (HR 17.9, 95%CI 4.4,72.5). Delirium after lung transplantation identifies a group at increased risk for poorer HRQL and death within the first post-operative year. Further studies should investigate potential causal links between delirium, and poorer HRQL and mortality risk after lung transplantation.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Trasplante de Pulmón
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Delirio
Tipo de estudio:
Prognostic_studies
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Qualitative_research
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Risk_factors_studies
Límite:
Aged
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article