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Characteristics and risk factors for SARS-CoV-2 in children tested in the early phase of the pandemic: a cross-sectional study, Italy, 23 February to 24 May 2020.
Lazzerini, Marzia; Sforzi, Idanna; Trapani, Sandra; Biban, Paolo; Silvagni, Davide; Villa, Giovanna; Tibaldi, Jessica; Bertacca, Luca; Felici, Enrico; Perricone, Giuseppina; Parrino, Roberta; Gioè, Claudia; Lega, Sara; Conte, Mariasole; Marchetti, Federico; Magista, Annamaria; Berlese, Paola; Martelossi, Stefano; Vaienti, Francesca; Valletta, Enrico; Mauro, Margherita; Dall'Amico, Roberto; Fasoli, Silvia; Gatto, Antonio; Chiaretti, Antonio; Dragovic, Danica; Pascolo, Paola; Pilotto, Chiara; Liguoro, Ilaria; Miorin, Elisabetta; Saretta, Francesca; Trobia, Gian Luca; Di Stefano, Antonella; Orlandi, Azzurra; Cardinale, Fabio; Lubrano, Riccardo; Testa, Alessia; Binotti, Marco; Moressa, Valentina; Barbi, Egidio; Armocida, Benedetta; Mariani, Ilaria.
Afiliación
  • Lazzerini M; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
  • Sforzi I; Department of Pediatric Emergency Medicine and Trauma Center, Meyer Children's University Hospital, Florence, Italy.
  • Trapani S; Department of Health Sciences and Meyer Children's University Hospital, Florence, Italy.
  • Biban P; Department of Neonatal and Paediatric Critical Care, Verona University Hospital, Verona Italy.
  • Silvagni D; Department of Neonatal and Paediatric Critical Care, Verona University Hospital, Verona Italy.
  • Villa G; Pediatric Emergency Unit, IRCCS Gaslini Children's Hospital, Genoa, Italy.
  • Tibaldi J; Pediatric Emergency Unit, IRCCS Gaslini Children's Hospital, Genoa, Italy.
  • Bertacca L; Pediatric Emergency Unit and Department of Pediatric and Neonatology, Misericordia Hospital, Grosseto, Italy.
  • Felici E; Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Perricone G; Pediatric and Pediatric Emergency Unit, The Children Hospital, AO SS Antonio e Biagio e Cesare Arrigo, Alessandria, Italy.
  • Parrino R; Pediatria d'Urgenza e Pronto Soccorso P.O.G. Di Cristina, Palermo, Italy.
  • Gioè C; Pediatric Infectious diseases, P.O.G. Di Cristina, Palermo, Italy.
  • Lega S; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
  • Conte M; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
  • Marchetti F; Department of Pediatrics, Ravenna Hospital, Ravenna, Italy.
  • Magista A; Department of Pediatrics, Community Pediatrics, Ravenna, Italy.
  • Berlese P; Department of Pediatrics, Treviso Hospital, Treviso, Italy.
  • Martelossi S; Department of Pediatrics, Treviso Hospital, Treviso, Italy.
  • Vaienti F; Department of Pediatrics, G.B. Morgagni-L. Pierantoni Hospital, Forlì, Italy.
  • Valletta E; Department of Pediatrics, G.B. Morgagni-L. Pierantoni Hospital, Forlì, Italy.
  • Mauro M; Department of Pediatrics and Neonatology, Santa Maria degli Angeli Hospital, Pordenone, Italy.
  • Dall'Amico R; Department of Pediatrics and Neonatology, Santa Maria degli Angeli Hospital, Pordenone, Italy.
  • Fasoli S; Paediatric Unit, Carlo Poma Hospital, Mantua, Italy.
  • Gatto A; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Chiaretti A; Department of Woman and Child Health and Public Health, Fondazione Policlinico Universitario A. Gemelli IRCCS, Rome, Italy.
  • Dragovic D; Department of Pediatrics, San Polo Hospital, ASUGI, Monfalcone (GO), Italy.
  • Pascolo P; Department of Pediatrics, San Polo Hospital, ASUGI, Monfalcone (GO), Italy.
  • Pilotto C; Division of Paediatrics, Department of Medicine DAME, Academic Hospital Santa Maria della Misericordia, University of Udine, Udine, Italy.
  • Liguoro I; Division of Paediatrics, Department of Medicine DAME, Academic Hospital Santa Maria della Misericordia, University of Udine, Udine, Italy.
  • Miorin E; Department of Pediatrics, Latisana-Palmanova, ASUFC, Udine, Italy.
  • Saretta F; Department of Pediatrics, Latisana-Palmanova, ASUFC, Udine, Italy.
  • Trobia GL; Pediatric and Pediatric Emergency Room Unit Cannizzaro Emergency Hospital, Catania, Italy.
  • Di Stefano A; Pediatric and Pediatric Emergency Room Unit Cannizzaro Emergency Hospital, Catania, Italy.
  • Orlandi A; Giovanni XXIII Pediatric Hospital, Department of Pediatrics, University of Bari, Bari, Italy.
  • Cardinale F; Giovanni XXIII Pediatric Hospital, Department of Pediatrics, University of Bari, Bari, Italy.
  • Lubrano R; Department of Pediatrics Sapienza University of Rome, Santa Maria Goretti Hospital, Latina, Italy.
  • Testa A; Department of Pediatrics Sapienza University of Rome, Santa Maria Goretti Hospital, Latina, Italy.
  • Binotti M; Neonatal and Pediatric Intensive Care Unit, Maggiore della Carità University Hospital, Novara, Italy.
  • Moressa V; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
  • Barbi E; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
  • Armocida B; University of Trieste, Trieste, Italy.
  • Mariani I; Institute for Maternal and Child Health - IRCCS "Burlo Garofolo", Trieste, Italy.
Euro Surveill ; 26(14)2021 04.
Article en En | MEDLINE | ID: mdl-33834960
ABSTRACT
BackgroundVery few studies describe factors associated with COVID-19 diagnosis in children.AimWe here describe characteristics and risk factors for COVID-19 diagnosis in children tested in 20 paediatric centres across Italy.MethodsWe included cases aged 0-18 years tested between 23 February and 24 May 2020. Our primary analysis focused on children tested because of symptoms/signs suggestive of COVID-19.ResultsAmong 2,494 children tested, 2,148 (86.1%) had symptoms suggestive of COVID-19. Clinical presentation of confirmed COVID-19 cases included besides fever (82.4%) and respiratory signs or symptoms (60.4%) also gastrointestinal (18.2%), neurological (18.9%), cutaneous (3.8%) and other unspecific influenza-like presentations (17.8%). In multivariate analysis, factors significantly associated with SARS-CoV-2 positivity were exposure history (adjusted odds ratio (AOR) 39.83; 95% confidence interval (CI) 17.52-90.55; p < 0.0001), cardiac disease (AOR 3.10; 95% CI 1.19-5.02; p < 0.0001), fever (AOR 3.05%; 95% CI 1.67-5.58; p = 0.0003) and anosmia/ageusia (AOR 4.08; 95% CI 1.69-9.84; p = 0.002). Among 190 (7.6%) children positive for SARS-CoV-2, only four (2.1%) required respiratory support and two (1.1%) were admitted to intensive care; all recovered.ConclusionRecommendations for SARS-CoV-2 testing in children should consider the evidence of broader clinical features. Exposure history, fever and anosmia/ageusia are strong risk factors in children for positive SARS-CoV-2 testing, while other symptoms did not help discriminate positive from negative individuals. This study confirms that COVID-19 was a mild disease in the general paediatric population in Italy. Further studies are needed to understand risk, clinical spectrum and outcomes of COVID-19 in children with pre-existing conditions.
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pandemias / Prueba de COVID-19 / COVID-19 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Europa Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Pandemias / Prueba de COVID-19 / COVID-19 Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adolescent / Child / Child, preschool / Female / Humans / Infant / Male / Newborn País/Región como asunto: Europa Idioma: En Año: 2021 Tipo del documento: Article