Acute retrobulbar optic neuritis with anti-myelin oligodendrocyte glycoprotein antibody-associated disease complicated with microscopic polyangiitis: A case report.
Medicine (Baltimore)
; 100(15): e24889, 2021 Apr 16.
Article
en En
| MEDLINE
| ID: mdl-33847609
ABSTRACT
RATIONALE Anti-myelin oligodendrocyte protein antibody-associated disease (MOGAD) is a new disease entity with various clinical phenotypes. MOGAD often present with recurrent optic neuritis (ON), and it can also develop as a compartment of neuromyelitis optica spectrum disorder (NMOSD). Moreover, multiple autoantibodies such as an anti-myeloperoxidase antineutrophil cytoplasmic antibody (MPO-ANCA) had been reported in the serum of patients with NMOSD. PATIENT CONCERNS We report an 86-year-old woman with a 2-year history of microscopic polyangiitis (MPA). The patient had a rapid loss of vision in her left eye. No abnormal findings were observed on her left fundus, and she tested negative for MPO-ANCA upon admission. However, anti-MOG antibodies were observed in the patient's serum and cerebrospinal fluid. DIAGNOSIS A diagnosis of MOGAD complicated with MPA was made. INTERVENTIONS:
The patient received twice steroid pulse therapy and oral azathioprine as maintenance therapy.OUTCOMES:
Her vision rapidly recovered, and no subsequent relapse was observed during the 8-month observation period.CONCLUSION:
To the best of our knowledge, this is the first case of MOGAD complicated with MPA, and steroid pulse therapy and azathioprine therapy were effective for ON caused by MOGAD.
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Enfermedades Autoinmunes
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Neuritis Óptica
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Glicoproteína Mielina-Oligodendrócito
Tipo de estudio:
Etiology_studies
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Risk_factors_studies
Límite:
Aged80
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Female
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article