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Increased serum chemerin levels associated with carotid intima-media thickness.
Demir, Caner Feyzi; Atas, Iklimya Nimet; Balgetir, Ferhat; Artas, Hakan; Gönen, Murat; Aydin, Süleyman.
Afiliación
  • Demir CF; Firat University, Faculty of Medicine, Department of Neurology, Elazig, Turkey.
  • Atas IN; Health Sciences University, Elazig Fethi Sekin City Hospital, Department of Neurology, Elazig, Turkey.
  • Balgetir F; Firat University, Faculty of Medicine, Department of Neurology, Elazig, Turkey.
  • Artas H; Firat University, Faculty of Medicine, Department of Radiology, Elazig, Turkey.
  • Gönen M; Firat University, Faculty of Medicine, Department of Neurology, Elazig, Turkey.
  • Aydin S; Firat University, Faculty of Medicine, Department of Medical Biochemistry and Clinical Biochemistry, Elazig, Turkey.
Arq Neuropsiquiatr ; 79(3): 189-194, 2021 03.
Article en En | MEDLINE | ID: mdl-33886791
ABSTRACT

BACKGROUND:

Elevated levels of chemerin can predict future ischemic cerebrovascular disease. Although chemerin is thought to play a role in atherosclerotic inflammation, whether circulating chemerin levels are associated with the severity of atherosclerosis remains to be determined.

OBJECTIVES:

Through the use of carotid Doppler ultrasonography, our aim in this study was to investigate the relationships of serum chemerin levels with carotid intima-media thickness (CIMT) as an indicator of generalized atherosclerosis.

METHODS:

This study compared 40 patients with ischemic stroke and 40 healthy subjects. Measurements were made at end-diastole using color Doppler ultrasonography (CDUS) after a 5-min rest interval in a quiet and dark room. CIMT was defined as the distance between the innermost edge of the luminal echo to the innermost edge of the media/adventitia echo. CIMT was measured in the posterior wall of both common carotid arteries within 1 cm proximally to the bulbus. Three measurements were made on both sides and the average measurement was taken as the CIMT. Serum chemerin levels were determined in all patients and healthy subjects.

RESULTS:

Serum chemerin levels were significantly higher in the patient group than in the control group (p=0.004). Serum chemerin levels were positively correlated with CIMT (p<0.05). There was a significant difference between the groups with regard to CIMT (p<0.001).

CONCLUSION:

Elevated serum chemerin levels appear to be associated with CIMT, thus suggesting that a link exists between chemerin and atherosclerotic ischemic cerebrovascular disease.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades de las Arterias Carótidas / Quimiocinas / Aterosclerosis / Grosor Intima-Media Carotídeo Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Enfermedades de las Arterias Carótidas / Quimiocinas / Aterosclerosis / Grosor Intima-Media Carotídeo Tipo de estudio: Diagnostic_studies / Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article