Image enhancement for fluorescence microscopy based on deep learning with prior knowledge of aberration.
Opt Lett
; 46(9): 2055-2058, 2021 May 01.
Article
en En
| MEDLINE
| ID: mdl-33929417
ABSTRACT
In this Letter, we propose a deep learning method with prior knowledge of potential aberration to enhance the fluorescence microscopy without additional hardware. The proposed method could effectively reduce noise and improve the peak signal-to-noise ratio of the acquired images at high speed. The enhancement performance and generalization of this method is demonstrated on three commercial fluorescence microscopes. This work provides a computational alternative to overcome the degradation induced by the biological specimen, and it has the potential to be further applied in biological applications.
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2021
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