Reduction-responsive dehydroepiandrosterone prodrug nanoparticles loaded with camptothecin for cancer therapy by enhancing oxidation therapy and cell replication inhibition.

Xu, Congjun; Yang, Haolan; Xiao, Zhanghong; Zhang, Tao; Guan, Zilin; Chen, Jie; Lai, Hualu; Xu, Xiaoyu; Huang, Yanjuan; Huang, Zeqian; Zhao, Chunshun

Xu, Congjun; Yang, Haolan; Xiao, Zhanghong; Zhang, Tao; Guan, Zilin; Chen, Jie; Lai, Hualu; Xu, Xiaoyu; Huang, Yanjuan; Huang, Zeqian; Zhao, Chunshun.

Afiliación

Xu C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Yang H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xiao Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhang T; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Guan Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Chen J; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Lai H; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Xu X; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Huang Y; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Huang Z; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China.
Zhao C; School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People's Republic of China. Electronic address: zhaocs@mail.sysu.edu.cn.

Int J Pharm ; 603: 120671, 2021 Jun 15.

Article en En | MEDLINE | ID: mdl-33961957

Asunto(s)

Nanopartículas; Neoplasias; Profármacos; Camptotecina; Línea Celular Tumoral; Replicación del ADN; Deshidroepiandrosterona/uso terapéutico; Sistemas de Liberación de Medicamentos; Humanos; Neoplasias/tratamiento farmacológico; Oxidación-Reducción; Profármacos/uso terapéutico

Palabras clave

Cell cycle arrest; GSH-responsive; Oxidation therapy; PEGylated prodrug; Pentose phosphate pathway

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Nanopartículas / Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Nanopartículas / Neoplasias Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article