Insulin-induced conformational changes in the full-length insulin receptor: structural insights gained from molecular modeling analyses.

Yang, Yong Xiao; Li, Peng; Wang, Pan; Zhu, Bao Ting

Yang, Yong Xiao; Li, Peng; Wang, Pan; Zhu, Bao Ting.

Afiliación

Yang YX; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China.
Li P; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China.
Wang P; Shenzhen Bay Laboratory, Shenzhen 518055, China.
Zhu BT; Shenzhen Key Laboratory of Steroid Drug Discovery and Development, School of Life and Health Sciences, The Chinese University of Hong Kong, Shenzhen 518172, China.

Acta Biochim Biophys Sin (Shanghai) ; 53(7): 848-869, 2021 Jul 05.

Article en En | MEDLINE | ID: mdl-33987639

Asunto(s)

Insulina/química; Modelos Moleculares; Receptor de Insulina/química; Humanos; Estructura Cuaternaria de Proteína

Palabras clave

conformational transition; full-length insulin receptor; insulin; molecular modeling analysis; receptor activation mechanism

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Receptor de Insulina / Modelos Moleculares / Insulina Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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