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Preclinical trial of a MAP4K4 inhibitor to reduce infarct size in the pig: does cardioprotection in human stem cell-derived myocytes predict success in large mammals?
Te Lintel Hekkert, Maaike; Newton, Gary; Chapman, Kathryn; Aqil, Rehan; Downham, Robert; Yan, Robert; Merkus, Daphne; Whitlock, Gavin; Lane, Charlotte A L; Cawkill, Darren; Perrior, Trevor; Duncker, Dirk J; Schneider, Michael D.
Afiliación
  • Te Lintel Hekkert M; Department of Cardiology (Thoraxcenter), Erasmus University Medical Center, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
  • Newton G; Domainex Ltd, Saffron Walden, UK.
  • Chapman K; Domainex Ltd, Saffron Walden, UK.
  • Aqil R; Domainex Ltd, Saffron Walden, UK.
  • Downham R; Domainex Ltd, Saffron Walden, UK.
  • Yan R; Domainex Ltd, Saffron Walden, UK.
  • Merkus D; Department of Cardiology (Thoraxcenter), Erasmus University Medical Center, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands.
  • Whitlock G; Sandexis Medicinal Chemistry, Sandwich, UK.
  • Lane CAL; Apollo Therapeutics, Stevenage, UK.
  • Cawkill D; Apollo Therapeutics, Stevenage, UK.
  • Perrior T; Domainex Ltd, Saffron Walden, UK.
  • Duncker DJ; Department of Cardiology (Thoraxcenter), Erasmus University Medical Center, University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands. d.duncker@erasmusmc.nl.
  • Schneider MD; National Heart and Lung Institute, Imperial College London, Du Cane Road, London, W12 0NN, UK. m.d.schneider@imperial.ac.uk.
Basic Res Cardiol ; 116(1): 34, 2021 05 20.
Article en En | MEDLINE | ID: mdl-34018053
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Proteínas Serina-Treonina Quinasas / Miocitos Cardíacos / Péptidos y Proteínas de Señalización Intracelular / Inhibidores de Proteínas Quinasas / Células Madre Pluripotentes Inducidas / Infarto del Miocardio Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Profármacos / Proteínas Serina-Treonina Quinasas / Miocitos Cardíacos / Péptidos y Proteínas de Señalización Intracelular / Inhibidores de Proteínas Quinasas / Células Madre Pluripotentes Inducidas / Infarto del Miocardio Tipo de estudio: Clinical_trials / Prognostic_studies / Risk_factors_studies Límite: Animals / Female / Humans Idioma: En Año: 2021 Tipo del documento: Article