Polymorphic SERPINA3-R124C reduces pathogenesis of its wild type by shortening the lifetime of oligomeric Aß.

Akbor, Maruf Mohammad; Kurosawa, Nobuyuki; Tanaka, Masashi; Isobe, Masaharu

Akbor, Maruf Mohammad; Kurosawa, Nobuyuki; Tanaka, Masashi; Isobe, Masaharu.

Afiliación

Akbor MM; Laboratory of Molecular and Cellular Biology, Department of Life Sciences and Bioengineering, Faculty of Engineering, University of Toyama, Toyama, Japan.
Kurosawa N; Laboratory of Molecular and Cellular Biology, Department of Life Sciences and Bioengineering, Faculty of Engineering, University of Toyama, Toyama, Japan.
Tanaka M; Department of Neurology, Juntendo University Graduate School of Medicine, Tokyo, Japan.
Isobe M; Laboratory of Molecular and Cellular Biology, Department of Life Sciences and Bioengineering, Faculty of Engineering, University of Toyama, Toyama, Japan.

Biosci Biotechnol Biochem ; 85(8): 1861-1868, 2021 Jul 23.

Article en En | MEDLINE | ID: mdl-34077500

Asunto(s)

Péptidos beta-Amiloides/metabolismo; Biopolímeros/metabolismo; Fragmentos de Péptidos/metabolismo; Serpinas/metabolismo; Péptidos beta-Amiloides/biosíntesis; Péptidos beta-Amiloides/química; Benzotiazoles/metabolismo; Western Blotting; Catálisis; Línea Celular Tumoral; Humanos; Microscopía Electrónica de Transmisión; Fragmentos de Péptidos/biosíntesis; Fragmentos de Péptidos/química; Conformación Proteica; Proteínas Recombinantes/química; Proteínas Recombinantes/metabolismo; Serpinas/química

Palabras clave

Alzheimer diseases; Aß42 oligomer; SERPINA3; benign chaperon; polymorphisms

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Fragmentos de Péptidos / Biopolímeros / Serpinas / Péptidos beta-Amiloides Tipo de estudio: Etiology_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article

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