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Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening.
Gradl, Stefan; Steuber, Holger; Weiske, Joerg; Szewczyk, Magda M; Schmees, Norbert; Siegel, Stephan; Stoeckigt, Detlef; Christ, Clara D; Li, Fengling; Organ, Shawna; Abbey, Megha; Kennedy, Steven; Chau, Irene; Trush, Viacheslav; Barsyte-Lovejoy, Dalia; Brown, Peter J; Vedadi, Masoud; Arrowsmith, Cheryl; Husemann, Manfred; Badock, Volker; Bauser, Marcus; Haegebarth, Andrea; Hartung, Ingo V; Stresemann, Carlo.
Afiliación
  • Gradl S; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Steuber H; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Weiske J; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Szewczyk MM; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Schmees N; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Siegel S; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Stoeckigt D; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Christ CD; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Li F; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Organ S; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Abbey M; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Kennedy S; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Chau I; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Trush V; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Barsyte-Lovejoy D; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Brown PJ; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Vedadi M; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Arrowsmith C; Structural Genomics Consortium, University of Toronto, Toronto, Canada.
  • Husemann M; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Badock V; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Bauser M; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Haegebarth A; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Hartung IV; Bayer AG, Global Drug Discovery, Berlin, Germany.
  • Stresemann C; Bayer AG, Global Drug Discovery, Berlin, Germany.
SLAS Discov ; 26(8): 947-960, 2021 09.
Article en En | MEDLINE | ID: mdl-34154424
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: N-Metiltransferasa de Histona-Lisina / Descubrimiento de Drogas / Ensayos Analíticos de Alto Rendimiento / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
Imprimir
XML
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: N-Metiltransferasa de Histona-Lisina / Descubrimiento de Drogas / Ensayos Analíticos de Alto Rendimiento / Antineoplásicos Tipo de estudio: Diagnostic_studies / Prognostic_studies / Screening_studies Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article