A four-oil intravenous lipid emulsion improves markers of liver function, triglyceride levels and shortens length of hospital stay in adults: a systematic review and meta-analysis.
Nutr Res
; 92: 1-11, 2021 08.
Article
en En
| MEDLINE
| ID: mdl-34157593
ABSTRACT
Clinical trials have reported that a four-oil intravenous lipid emulsion (SMOFlipid) play a positive role in immune function, but showed inconsistent outcomes compared to other lipid emulsions. A systematic review and meta-analysis was conducted to evaluate the effect of SMOFlipid on liver function, triglycerides (TG), inflammatory markers, and clinical outcomes in hospitalized adults after short-term use compared to others. A search of the PubMed, Medline, Embase, China National Knowledge Infrastructure, and Wanfang databases was performed to identify the included randomized controlled trials. Trials with adults who were administrated a short-term course of SMOFlipid were included. A meta-analysis on liver function markers, TG, inflammatory markers, and clinical outcomes was conducted. A total of 18 randomized controlled trials with 1188 patients were included. Compared to other lipid emulsions, SMOFlipid was associated with a significant reduction in ALT, AST, γ-glutamyltransferase, total bilirubin, TG, C-reactive protein and length of hospital stay. No effect on serum interleukin-6 levels or adverse events were observed. For adult patients, our meta-analysis indicated that SMOFlipid may be beneficial to the liver and prone to prevent hyperlipidemia. The SMOFlipid also shortened length of hospital stay.
Palabras clave
Texto completo:
1
Banco de datos:
MEDLINE
Asunto principal:
Triglicéridos
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Aceite de Soja
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Aceites de Pescado
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Ácidos Grasos Omega-3
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Nutrición Parenteral
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Emulsiones Grasas Intravenosas
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Aceite de Oliva
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Tiempo de Internación
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Hígado
Tipo de estudio:
Clinical_trials
/
Systematic_reviews
Límite:
Adult
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Humans
Idioma:
En
Año:
2021
Tipo del documento:
Article