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Bleeding Risk and Mortality Associated With Uninterrupted Antithrombotic Therapy During Percutaneous Endoscopic Gastrostomy Tube Placement.
Thosani, Nirav; Rashtak, Shahrooz; Kannadath, Bijun Sai; Munjal, Akhil; Meriwether, Matthew; Yoon, Eric D; Hermann, Andrew; Ali, Sara; Haddad, Paul G; Patil, Prithvi; Ramireddy, Srinivas; Badillo, Ricardo; DaVee, R Tomas; Guha, Sushovan.
Afiliación
  • Thosani N; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Rashtak S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Kannadath BS; Division of Gastroenterology and Hepatology, Department of Internal Medicine, University of Arizona College of Medicine at Phoenix, Phoenix, Arizona, USA.
  • Munjal A; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Meriwether M; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Yoon ED; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Hermann A; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Ali S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Haddad PG; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Patil P; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Ramireddy S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Badillo R; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • DaVee RT; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
  • Guha S; Division of Gastroenterology, Hepatology, and Nutrition, Department of Internal Medicine, McGovern Medical School at UTHealth, Houston, Texas, USA.
Am J Gastroenterol ; 116(9): 1868-1875, 2021 09 01.
Article en En | MEDLINE | ID: mdl-34158462
ABSTRACT

INTRODUCTION:

Antithrombotic therapy is often interrupted before the placement of a percutaneous endoscopic gastrostomy (PEG) tube because of potentially increased risk of hemorrhagic events. The aim of our study was to evaluate the risk of bleeding events and overall complication rates after PEG in patients on uninterrupted antiplatelet and anticoagulation therapy in a high-volume center.

METHODS:

Data regarding demographics, diagnoses, comorbidities, and clinical outcomes pertinent to PEG were collected from 2010 to 2016. Furthermore, data regarding antithrombotic therapy along with the rate of minor or major complications including bleeding associated with this procedure were analyzed. Significant bleeding was defined as postprocedure bleeding from PEG site requiring a blood transfusion and/or surgical/endoscopic intervention.

RESULTS:

We included 1,613 consecutive PEG procedures in this study, of which 1,540 patients (95.5%) received some form of uninterrupted antithrombotic therapy. Of those patients, 535 (34.7%) were on aspirin, 256 (16.6%) on clopidogrel, and 119 (7.7%) on both aspirin and clopidogrel. Subcutaneous heparin was uninterrupted in 980 (63.6%), intravenous heparin in 34 (2.1%), warfarin in 168 (10.9%), and direct-acting oral anticoagulation in 82 (5.3%) patients who overlapped on multiple drugs. We observed 6 significant bleeding events in the entire cohort (0.39%), and all were in subcutaneous heparin groups either alone or in combination with aspirin. No clinically significant bleeding was noted in patients on uninterrupted aspirin, warfarin, clopidogrel, or direct-acting oral anticoagulation groups. Only 5 patients (0.31%) had PEG-related mortality.

DISCUSSION:

The risk of significant bleeding associated with the PEG placement was minimal in patients on uninterrupted periprocedural antithrombotic therapy.
Asunto(s)

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gastrostomía / Fibrinolíticos / Hemorragia Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2021 Tipo del documento: Article

Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Gastrostomía / Fibrinolíticos / Hemorragia Tipo de estudio: Etiology_studies / Risk_factors_studies Límite: Aged / Aged80 / Female / Humans / Male / Middle aged Idioma: En Año: 2021 Tipo del documento: Article