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Switching Lysophosphatidylserine G Protein-Coupled Receptor Agonists to Antagonists by Acylation of the Hydrophilic Serine Amine.
Sayama, Misa; Uwamizu, Akiharu; Ikubo, Masaya; Chen, Luying; Yan, Ge; Otani, Yuko; Inoue, Asuka; Aoki, Junken; Ohwada, Tomohiko.
Afiliación
  • Sayama M; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Uwamizu A; Department of Health Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Ikubo M; AMED-LEAP, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan.
  • Chen L; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Yan G; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Otani Y; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Inoue A; Department of Organic and Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
  • Aoki J; AMED-LEAP, Japan Science and Technology Corporation, Kawaguchi 332-0012, Japan.
  • Ohwada T; Laboratory of Molecular and Cellular Biochemistry, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, Miyagi 980-8578, Japan.
J Med Chem ; 64(14): 10059-10101, 2021 07 22.
Article en En | MEDLINE | ID: mdl-34233115
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Lisofosfolípidos / Receptores Acoplados a Proteínas G / Aminas Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article
Texto completo
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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Serina / Lisofosfolípidos / Receptores Acoplados a Proteínas G / Aminas Límite: Humans Idioma: En Año: 2021 Tipo del documento: Article