Recombinant platelet-derived growth factor-BB alleviates osteoarthritis in a rat model by decreasing chondrocyte apoptosis in vitro and in vivo.

Zhu, Pengfei; Wang, Zhengchao; Sun, Zhenxing; Liao, Bokai; Cai, Yu

Zhu, Pengfei; Wang, Zhengchao; Sun, Zhenxing; Liao, Bokai; Cai, Yu.

Afiliación

Zhu P; Department of Cardiology, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Wang Z; Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Sun Z; Department of Ultrasound, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Liao B; School of Chemistry and Chemical Engineering, Guangzhou University, Guangzhou, China.
Cai Y; Department of Rehabilitation, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.

J Cell Mol Med ; 25(15): 7472-7484, 2021 08.

Article en En | MEDLINE | ID: mdl-34250725

Asunto(s)

Apoptosis; Becaplermina/uso terapéutico; Condrocitos/efectos de los fármacos; Osteoartritis/tratamiento farmacológico; Animales; Becaplermina/farmacología; Caspasa 3/metabolismo; Células Cultivadas; Condrocitos/metabolismo; Colágeno/metabolismo; Masculino; Ratas; Ratas Sprague-Dawley; Proteínas Recombinantes/farmacología; Proteínas Recombinantes/uso terapéutico; Proteína X Asociada a bcl-2/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo

Palabras clave

apoptosis; knee; osteoarthritis; platelet-derived growth factor

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Texto completo: 1 Banco de datos: MEDLINE Asunto principal: Osteoartritis / Apoptosis / Condrocitos / Becaplermina Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Año: 2021 Tipo del documento: Article

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